I have two items so far that might be worthy:
Josh Towers throws a complete game, 2-hit shutout
http://fantasygames.sportingnews.com/baseball/stratomatic/2006/league/boxscore.html?group_id=206&g_id=13
And this next one isn't only one game, but I think it warrants mention as it's quite odd. Javier Valentin, a man who hit 14 homers all last year, hits 4 homers in the first series of the year (at Petco, too! :shock: )
http://fantasygames.sportingnews.com/baseball/stratomatic/2006/league/boxscore.html?group_id=205&g_id=13