Pretty much all the arguments from both sides have been sorted out.
In autodraft, it is obvious that one-sided teams pays, but contrary to many voices, I tend to agree with Jerlins point even in vet leagues. Too few owners, even in vet leagues, adjust themselves to one-sided line-ups, so that, very often, it pays to be one-sided.
That being said, you have to be clever in your "one-sideness". Say you go for a Wrigley team. Say that you end up at ss with, say, Clayton--a rather weak hitter. There is no need to have this right-handed hitter--and be exposed to adjustments of opponent owners--for a player who is not well adjusted to the stadium.
However, if you end up, after the draft, with Rolen, ARod, Boone, AJones, etc, then I would give it a shot, even in vet leagues.