I won a league with multiple platoons once, but it was a 3.00 or less pitcher league so I had plenty of money. I drafted all the best 3.00 and under pitchers then went with Whitaker / White, Dykstra / Lemon, Oliva / Horton, Prothro / A. Smith, and Freehan / O'Neil.
Led the league in pitching, had great defense and finished in the middle on offense. An upside to the platoons is during injuries you have a more competant backup than usual!
Dykstra / Flood is one of my faves - I have always loved platoons!