I've never played before in a league with advanced injuries on. How deep does your bullpen need to be?
It's ugly. I may be biased but I like the advanced injury rule as it is another feature of this league that recreates the real world experience of managing an MLB roster. Depth is critical, especially around starting pitching. If you have a high injury position player and don't have a decent back up then you could be in trouble. You also need bullpen depth, especially if you have a high injury risk player or two in your pen. If not, you can find yourself taxing your short staffed pen pretty quickly.
I lost 414 games to player injuries last year with Shelby Miller missing 72 games, Taylor Walls missing 60, Glasnow missing 41, and Stanton missing 35. Two teams lost more than 500 games to player injuries. It's rare for a team to lost more than 200 player games to injuries with the regular rules, while it's rare for a team to lose LESS THAN 200 player games to injuries in the advanced rules.
I think the advanced injury rules make it a different game.