I'm pretty much with Badjam on this. My own approach is to try construct teams that win by scoring a bunch more runs than they give up. If a team can do that, it will win more often than it loses, most of the time. The bigger the team's positive run differential, the more games it's likely to win.
Online Strat-O-matic lends itself to this kind of job-lot baseball. The quirks of how HAL manages or mismanages a team on a game by game basis, will, to my way of thinking, mostly even out.
If I sweated out the play-by-play, I'd likely go crazy.