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- Joined: Thu Aug 23, 2012 11:32 pm
Except in case of injury, the rule is a pitcher must pitch to one full batter (or until the side is retired*) before being removed. However, once he has met that requirement, he may be substituted for at any time--including in the middle of an at bat.
*A pitcher could enter the game with two outs, pick off a runner, and be legally removed without ever throwing a pitch.
Rule 3.05 covers this: http://mlb.mlb.com/mlb/downloads/y2013/ ... _rules.pdf